Can Deathtouch combine with Trample?

Yes. With both, the attacker only needs to assign 1 lethal damage to each blocker, and the rest can trample over to the player or planeswalker.

Does first strike stop Deathtouch?

If a first striker without Deathtouch kills the Deathtouch creature before normal combat damage, the Deathtouch creature deals no damage back; but if the Deathtouch creature also has first strike or survives, its Deathtouch still applies.

What is the best Deathtouch card?

By popularity, Deathtouch is among the most-played Deathtouch cards — see the full ranked list above.

Best Deathtouch cards in MTG

Deathtouch: Any amount of damage dealt by a source with Deathtouch is enough to destroy the creature it is dealt to.

Deathtouch turns even a 1/1 into a deterrent that can trade with the biggest creatures on the board, making it excellent for defensive decks and ping effects. Pair it with Trample so excess damage spills over, or with first strike to kill blockers before they can deal damage back. It also shines on creatures that deal damage to multiple targets, like those that fight or deal combat damage to several blockers.

FAQ

Can Deathtouch combine with Trample?: Yes. With both, the attacker only needs to assign 1 lethal damage to each blocker, and the rest can trample over to the player or planeswalker.
Does first strike stop Deathtouch?: If a first striker without Deathtouch kills the Deathtouch creature before normal combat damage, the Deathtouch creature deals no damage back; but if the Deathtouch creature also has first strike or survives, its Deathtouch still applies.
What is the best Deathtouch card?: By popularity, Deathtouch is among the most-played Deathtouch cards — see the full ranked list above.