Windfall + Tainted Strike + Nekusar, the Mindrazer

Prerequisites

A player has a number of cards in hand that is greater than or equal to 10 minus the lowest amount of poison counters an opponent has.

Steps

1. Cast Tainted Strike by paying {B}, giving Nekusar infect until end of turn.
2. Cast Windfall by paying {2}{U}, causing each player to discard their hand and then draw a number of cards equal to the greatest number of cards a player discarded this way.
3. Nekusar triggers for each card drawn this way, giving each opponent a poison counter for each card they drew.
4. Each opponent loses the game due to having ten or more poison counters