Fate Unraveler + Echo of Eons + Phyresis

Prerequisites

Phyresis attached to Fate Unraveler.

Steps

1. Cast Echo of Eons by paying {4}{U}{U}, causing each player to shuffle their hand and graveyard into their library and draw seven cards.
2. Fate Unraveler triggers for each card your opponent draw this way, giving each opponent seven poison counters.
3. Cast Echo of Eons from your graveyard for its flashback cost by paying {2}{U}, causing each player to shuffle their hand and graveyard into their library, draw seven cards, and exile Echo of Eons.
4. Fate Unraveler triggers for each card your opponent draw this way, giving each opponent seven poison counters.
5. Each opponent loses the game due to having ten or more poison counters.